UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 10 von 56
Datensatz exportieren als...
BibTeX
Up‐regulation of the protein tyrosine phosphatase SHP‐1 in human breast cancer and correlation with GRB2 expression
International journal of cancer, 2000-11, Vol.88 (3), p.363-368
Yip, Sonia S.
Crew, A. Jayne
Gee, Julia M.W.
Hui, Rina
Blamey, Roger W.
Robertson, John F.R.
Nicholson, Robert I.
Sutherland, Robert L.
Daly, Roger J.
2000
Details
Autor(en) / Beteiligte
Yip, Sonia S.
Crew, A. Jayne
Gee, Julia M.W.
Hui, Rina
Blamey, Roger W.
Robertson, John F.R.
Nicholson, Robert I.
Sutherland, Robert L.
Daly, Roger J.
Titel
Up‐regulation of the protein tyrosine phosphatase SHP‐1 in human breast cancer and correlation with GRB2 expression
Ist Teil von
International journal of cancer, 2000-11, Vol.88 (3), p.363-368
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
2000
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The protein tyrosine phosphatase SHP‐1 is predominantly expressed in hemopoietic cell lineages, where its function is relatively well defined. However, its expression profile also extends to certain epithelial cell types. Furthermore, the negative regulatory role of this enzyme in hemopoietic cell signaling may not apply to other systems, where positive effects on particular tyrosine kinase signaling pathways have been described. Expression of SHP‐1 was therefore investigated in human breast cancer cell lines and primary breast cancers. Differential expression of SHP‐1 mRNA was observed among the 19 breast cancer cell lines examined, and in an analysis of 72 primary breast cancers, SHP‐1 mRNA expression was increased 2‐ to 12‐fold relative to normal breast epithelial cells in 58% of the samples. Interestingly, a subset of the cancers also over‐expressed GRB2 mRNA by 2‐ to 7‐fold, and a significant (p < 0.01) positive correlation was observed between SHP‐1 and GRB2 mRNA expression. Since these proteins can bind to each other and regulate MEK/MAP kinase activation, their co‐ordinate up‐regulation may amplify tyrosine kinase signaling in breast cancer cells. Int. J. Cancer 88:363–368, 2000. © 2000 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/1097-0215(20001101)88:3<363::AID-IJC7>3.0.CO;2-4
Titel-ID: cdi_proquest_miscellaneous_72377626
Format
–
Schlagworte
Adaptor Proteins, Signal Transducing
,
Biological and medical sciences
,
Breast Neoplasms - metabolism
,
Cell Line
,
Female
,
Gene Expression Regulation, Neoplastic
,
GRB2 Adaptor Protein
,
Gynecology. Andrology. Obstetrics
,
Humans
,
Intracellular Signaling Peptides and Proteins
,
Mammary gland diseases
,
Medical sciences
,
ombinMicr
,
Protein Tyrosine Phosphatase, Non-Receptor Type 11
,
Protein Tyrosine Phosphatase, Non-Receptor Type 6
,
Protein Tyrosine Phosphatases - genetics
,
Proteins - genetics
,
Receptor, Epidermal Growth Factor - analysis
,
Receptors, Estrogen - analysis
,
RNA, Messenger - analysis
,
Tumors
,
Up-Regulation
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX