Details

Autor(en) / Beteiligte

• CICHON, Sven
• SCHUMACHER, Johannes
• BORRMANN-HASSENBACH, Margitta
• FRANZEK, Ernst
• LANCZIK, Mario
• FRITZE, Jürgen
• KREINER, Roland
• REUNER, Ulrike
• WEIGELT, Bettina
• MINGES, Jürgen
• LICHTERMANN, Dirk
• LERER, Bernhard
• MÜLLER, Daniel J
• KANYAS, Kyra
• BAUR, Max P
• WIENKER, Thomas F
• MAIER, Wolfgang
• RIETSCHEL, Marcella
• PROPPING, Peter
• NÖTHEN, Markus M
• HÜRTER, Martina
• WINDEMUTH, Christine
• STRAUCH, Konstantin
• HEMMER, Susanne
• SCHULZE, Thomas G
• SCHMIDT-WOLF, Gabriele
• ALBUS, Margot

Titel

A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q

Ist Teil von

• Human molecular genetics, 2001-12, Vol.10 (25), p.2933-2944

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2001

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Bipolar affective disorder (BPAD), also known as manic depressive illness, is a severe psychiatric disorder characterized by episodes of mania and depression. It has a lifetime prevalence of approximately 1% in all human populations. In order to identify chromosomal regions containing genes that play a role in determining susceptibility to this psychiatric condition, we have conducted a complete genome screen with 382 markers (average marker spacing of 9.3 cM) in a sample of 75 BPAD families which were recruited through an explicit ascertainment scheme. Pedigrees were of German, Israeli and Italian origin, respectively. Parametric and non-parametric linkage analysis was performed. The highest two-point LOD score was obtained on 8q24 (D8S514; LOD score = 3.62), in a region that has not attracted much attention in previous linkage studies of BPAD. The second best finding was seen on 10q25-q26 (D10S217; LOD score = 2.86) and has been reported in independent studies of BPAD. Other regions showing 'suggestive' evidence for linkage localized to 1p33-p36, 2q21-q33, 3p14, 3q26-q27, 6q21-q22, 8p21, 13q11 and 14q12-q13. In addition, we aimed at detecting possible susceptibility loci underlying genomic imprinting by analyzing the autosomal genotype data with the recently developed extension of the GENEHUNTER program, GENEHUNTER-IMPRINTING. Putative paternally imprinted loci were identified in chromosomal regions 2p24-p21 and 2q31-q32. Maternally imprinted susceptibility genes may be located on 14q32 and 16q21-q23.