Trends in neurosciences (Regular ed.), 2000-10, Vol.23 (10), p.S86-S91
2000
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- Autor(en) / Beteiligte
- Titel
- Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism
- Ist Teil von
- Trends in neurosciences (Regular ed.), 2000-10, Vol.23 (10), p.S86-S91
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2000
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Characteristic changes involving interactions between dopamine and glutamate in striatal medium spiny neurons now appear to contribute to symptom production in Parkinson's disease (PD). The balance between kinase and phosphatase signaling modifies the phosphorylation state of glutamate receptors and thus their synaptic strength. Sensitization of spiny-neuron NMDA and AMPA receptors alters cortical glutamatergic input to the striatum and modifies striatal GABAergic output, and thus motor function. Conceivably, the pharmacological targeting of spiny-neuron mechanisms modified in PD will provide a safer and more effective therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0166-2236eISSN: 1878-108XDOI: 10.1016/S1471-1931(00)00018-5Titel-ID: cdi_proquest_miscellaneous_72369377
- Format
- –
- Schlagworte
- Animals, Antiparkinson Agents - pharmacology, Biological and medical sciences, Corpus Striatum - metabolism, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Dopamine - metabolism, Glutamic Acid - metabolism, Humans, Levodopa - pharmacology, Medical sciences, Models, Neurological, Neurology, Neurons, Efferent - metabolism, Neurons, Efferent - ultrastructure, Parkinsonian Disorders - metabolism, Phosphotransferases - metabolism, Receptors, Dopamine - metabolism, Receptors, Glutamate - metabolism, Signal Transduction, spiny neurons