Details

Autor(en) / Beteiligte

• Fort, Diana M
• Ubillas, Rosa P
• Mendez, Christopher D
• Jolad, Shivanand D
• Inman, Wayne D
• Carney, John R
• Chen, Jian Lu
• Ianiro, Teodoro T
• Hasbun, Carlos
• Bruening, Reimar C
• Luo, Jian
• Reed, Michael, J
• Iwu, Maurice
• Carlson, Thomas J
• King, Steven R
• Bierer, Donald E
• Cooper, Raymond

Titel

Novel Antihyperglycemic Terpenoid-Quinones from Pycnanthus angolensis

Ist Teil von

• Journal of organic chemistry, 2000-10, Vol.65 (20), p.6534-6539

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2000

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Two new compounds, pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from leaves and stems of the African plant, Pycnanthus angolensis (Welw.) Warb (Myristicaceae), by bioassay-guided fractionation of an ethanolic extract using a diabetic mouse model. Pycnanthuquinones A and B are the first representatives of a novel terpenoid-type quinone skeleton, and both compounds possess significant antihyperglycemic activity.