Details

Autor(en) / Beteiligte

• Moe, L.
• Gamlem, H.
• Jónasdóttir, T.J.
• Lingaas, F.

Titel

Renal Microcystic Tubular Lesions in Two 1Year-old Dogs – An Early Sign of Hereditary Renal Cystadenocarcinoma?

Ist Teil von

• Journal of comparative pathology, 2000-08, Vol.123 (2-3), p.218-221

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2000

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• As a part of a study of early renal changes in renal cystadenocarcinoma (RC), a 5-year-old German shepherd dog and two 1-year-old German shepherd mixed-breed dogs were examined. All three animals had bilateral, microscopic renal cysts, and the 5-year-old dog also had RC. Microscopical examination showed papillary hyperplastic tubular epithelial cells lining the inner wall of the renal cysts in all dogs. These cells showed strong reactivity with a monoclonal antibody against a broad-spectrum type of cytokeratin. The dam of the young dogs had suffered from autosomal dominant inherited RC and nodular dermatofibrosis (ND) syndrome. It is likely that the microscopic renal cystic lesions seen in the young dogs represented an early renal change in the RC/ND syndrome. This suggests that the diagnosis of RC can be made on suspected carriers by microscopical examination of renal biopsies as early as 1 year of age, i.e., before the dogs are used for breeding.