Details

Autor(en) / Beteiligte

• Okamoto, Hirokazu
• Taguchi, Hirohisa
• Iida, Kotaro
• Danjo, Kazumi

Titel

Development of polymer film dosage forms of lidocaine for buccal administration: I. Penetration rate and release rate

Ist Teil von

• Journal of controlled release, 2001-12, Vol.77 (3), p.253-260

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2001

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• We examined the penetration rate of lidocaine (LC) through excised oral mucosa from hamster cheek pouch and the in vitro release rate of LC from film dosage forms with hydroxypropylcellulose (HPC) as a film base. Addition of glycyrrhizic acid (GL) to the HPC films increased the LC release rate almost GL-content-dependently, while an optimum GL content was observed for the LC penetration rate. No LC penetration was observed from an acidic aqueous solution (pH 3.4) of LC, suggesting only unionized LC can substantially penetrate through the mucosa. A significant relationship between the penetration rate of LC and the release rate of unionized LC was found, suggesting that the in vitro dissolution study is a useful tool to predict the penetration rate taking the unionized drug fraction into consideration.