Details

Autor(en) / Beteiligte

• Wright, Peter F.
• Karron, Ruth A.
• Belshe, Robert B.
• Thompson, Juliette
• Crowe, James E.
• Boyce, Thomas G.
• Halburnt, Lisa L.
• Reed, George W.
• Whitehead, Stephen S.
• Anderson, Edwin L.
• Wittek, Alec E.
• Casey, Roberta
• Eichelberger, Maryna
• Thumar, Bhagvanji
• Randolph, Valerie B.
• Udem, Stephen A.
• Chanock, Robert M.
• Murphy, Brian R.

Titel

Evaluation of a Live, Cold-Passaged, Temperature-Sensitive, Respiratory Syncytial Virus Vaccine Candidate in Infancy

Ist Teil von

• The Journal of infectious diseases, 2000-11, Vol.182 (5), p.1331-1342

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2000

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• A live-attenuated, intranasal respiratory syncytial virus (RSV) candidate vaccine, cpts-248/404, was tested in phase 1 trials in 114 children, including 37 1–2-month-old infants—a target age for RSV vaccines. The cpts-248/404vaccine was infectious at 104 and 105 plaque-forming units in RSV-naive children and was broadly immunogenic in children >6 months old. Serum and nasal antibody responses in 1–2 month olds were restricted to IgA, had a dominant response to RSV G protein, and had no increase in neutralizing activity. Nevertheless, there was restricted virus shedding on challenge with a second vaccine dose and preliminary evidence for protection from symptomatic disease on natural reexposure. The cpts-248/404vaccine candidate did not cause fever or lower respiratory tract illness. In the youngest infants, however, cpts-248/404was unacceptable because of upper respiratory tract congestion associated with peak virus recovery. A live attenuated RSV vaccine for the youngest infant will use cpts-248/404 modified by additional attenuating mutations.