Details

Autor(en) / Beteiligte

• Sakaguchi, Shimon
• Sakaguchi, Noriko
• Shimizu, Jun
• Yamazaki, Sayuri
• Sakihama, Toshiko
• Itoh, Misako
• Kuniyasu, Yuhshi
• Nomura, Takashi
• Toda, Masaaki
• Takahashi, Takeshi

Titel

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Ist Teil von

• Immunological reviews, 2001-08, Vol.182 (1), p.18-32

Ort / Verlag

Copenhagen: Munksgaard International Publishers

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• There is accumulating evidence that T‐cell‐mediated dominant control of self‐reactive T‐cells contributes to the maintenance of immunologic self‐tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T‐cell population have revealed that CD25+ cells in the CD4+ population in normal naive animals bear the ability to prevent autoimmune disease in vivo and, upon antigenic stimulation, suppress the activation/proliferation of other T cells in vitro. The CD25+ CD4+ regulatory T cells, which are naturally anergic and suppressive, appear to be produced by the normal thymus as a functionally distinct subpopulation of T cells. They play critical roles not only in preventing autoimmunity but also in controlling tumor immunity and transplantation tolerance.