Nature medicine, 2000-10, Vol.6 (10), p.1160-1166
2000
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- Autor(en) / Beteiligte
- Titel
- Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine
- Ist Teil von
- Nature medicine, 2000-10, Vol.6 (10), p.1160-1166
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2000
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-8956eISSN: 1546-170XDOI: 10.1038/80506Titel-ID: cdi_proquest_miscellaneous_72308397
- Format
- –
- Schlagworte
- Amino Acid Sequence, Angiogenesis, Animals, Antigens, CD - immunology, Autoantibodies - immunology, Cancer therapies, Cancer Vaccines - pharmacology, Care and treatment, Cattle, CD4-Positive T-Lymphocytes - immunology, Cells, Cultured, Cross Reactions, Drug dosages, Endothelium, Endothelium - cytology, Endothelium - immunology, Endothelium, Vascular - cytology, Endothelium, Vascular - immunology, Health aspects, Humans, Immunoglobulins, Immunotherapy, Immunotherapy - methods, Integrin alphaV, Lymphocytes, Mice, Molecular Sequence Data, Neoplasms, Experimental - therapy, Neovascularization, Pathologic - drug therapy, Neovascularization, Pathologic - immunology, Peptides - immunology, Prevention, Proteins, Receptor Protein-Tyrosine Kinases - immunology, Receptors, Growth Factor - immunology, Receptors, Vascular Endothelial Growth Factor, Tumors, Vaccines