Details

Autor(en) / Beteiligte

• Kim, Dooseop
• Wang, Liping
• Caldwell, Charles G.
• Chen, Ping
• Finke, Paul E.
• Oates, Bryan
• MacCoss, Malcolm
• Mills, Sander G.
• Malkowitz, Lorraine
• Gould, Sandra L.
• DeMartino, Julie A.
• Springer, Martin S.
• Hazuda, Daria
• Miller, Michael
• Kessler, Joseph
• Danzeisen, Renee
• Carver, Gwen
• Carella, Anthony
• Holmes, Karen
• Lineberger, Janet
• Schleif, William A.
• Emini, Emilio A.

Titel

Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2001-12, Vol.11 (24), p.3099-3102

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2001

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described. A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.