Journal of natural products (Washington, D.C.), 2001-11, Vol.64 (11), p.1483-1485
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum
- Ist Teil von
- Journal of natural products (Washington, D.C.), 2001-11, Vol.64 (11), p.1483-1485
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2001
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0163-3864eISSN: 1520-6025DOI: 10.1021/np0103158Titel-ID: cdi_proquest_miscellaneous_72299598
- Format
- –
- Schlagworte
- Antineoplastic Agents, Phytogenic - chemistry, Antineoplastic Agents, Phytogenic - isolation & purification, Antineoplastic Agents, Phytogenic - pharmacology, Benzopyrans - chemistry, Benzopyrans - isolation & purification, Benzopyrans - pharmacology, Biological and medical sciences, Fabaceae - chemistry, General pharmacology, Humans, Isoflavones - chemistry, Isoflavones - isolation & purification, Isoflavones - pharmacology, Medical sciences, Molecular Structure, Nasopharyngeal Neoplasms, Nuclear Magnetic Resonance, Biomolecular, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, Phenols - chemistry, Phenols - isolation & purification, Phenols - pharmacology, Plant Stems - chemistry, Plants, Medicinal - chemistry, Pterocarpans, Structure-Activity Relationship, Tumor Cells, Cultured - drug effects, Tumor Cells, Cultured - enzymology