Details

Autor(en) / Beteiligte

• Egan, James F.X.
• Malakh, Lillian
• Turner, Garry W.
• Markenson, Glenn
• Wax, Joseph R.
• Benn, Peter A.

Titel

Role of ultrasound for Down syndrome screening in advanced maternal age

Ist Teil von

• American journal of obstetrics and gynecology, 2001-11, Vol.185 (5), p.1028-1031

Ort / Verlag

Philadelphia, PA: Mosby, Inc

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: To determine the sensitivity and false-positive rate of Down syndrome screening by use of maternal serum screen and the genetic sonogram in women ≥35 years of age. Study Design: We searched our perinatal databases retrospectively from January 1992 to January 2000 for the following criteria: known Down syndrome fetus or newborn, advanced maternal age, and genetic sonogram from 14-24 weeks’ gestation. The a priori maternal age or maternal serum screen risk was modified by likelihood ratios for ultrasound markers. Without markers the risk was reduced by 50%. The cut-off was 1:270. Results: Age and maternal serum screen had a sensitivity of 90.5% and a false-positive rate of 27.1%. Age and ultrasound had a 95.2% sensitivity and 43.5% false-positive rate, whereas the combination of age, maternal serum screen, and ultrasound had a 97.6% sensitivity and a 22.0% false-positive rate. Conclusion: The combination of age, maternal serum screen, and ultrasound improves the sensitivity for Down syndrome detection in the advanced maternal age population. (Am J Obstet Gynecol 2001;185:·1028-31.)