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Effect of intravenous taurine on endotoxin-induced acute lung injury in sheep
The European journal of surgery, 2001-08, Vol.167 (8), p.575-580
Egan, Bridget M.
Abdih, Hazem
Kelly, Cathal J.
Condron, Claire
Bouchier-Hayes, David J.
2001
Details
Autor(en) / Beteiligte
Egan, Bridget M.
Abdih, Hazem
Kelly, Cathal J.
Condron, Claire
Bouchier-Hayes, David J.
Titel
Effect of intravenous taurine on endotoxin-induced acute lung injury in sheep
Ist Teil von
The European journal of surgery, 2001-08, Vol.167 (8), p.575-580
Ort / Verlag
UK: Taylor & Francis, Ltd
Erscheinungsjahr
2001
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Objective: To find out if pretreatment with taurine would reduce the severity of endotoxin‐induced acute lung injury in a large animal model. Design: Randomised controlled study under licence from the Department of Health. Setting: Department of Surgical Research, Ireland. Animals: 15 male Suffolk sheep. Interventions: Vascular catheters were placed in the femoral artery and vein and a Swan‐Ganz catheter in the external jugular vein under general anaesthetic. Animals were randomized into three groups: control with measurements taken at baseline and half hourly up to 90 minutes; endotoxin, given Escherichia coli endotoxin intravenously after baseline measurements and taurine given 300 mg/kg 1 hour before endotoxin was given. Main outcome measures: Mean systemic arterial pressure, mean pulmonary arterial pressure, arterial oxygen tension (pO2), pulmonary myeloperoxidase activity, and neutrophil respiratory burst activity. Results: Endotoxin induced a severe lung injury characterised by a decrease in mean systemic blood pressure and an increase in pulmonary artery pressure, hypoxia, and an increase in pulmonary myeloperoxidase activity. Pretreatment with intravenous taurine significantly reduced these haemodynamic changes. It reduced pulmonary myeloperoxidase activity and peripheral neutropenia and increased neutrophil respiratory burst activity. Conclusions: This data suggest that taurine may have a therapeutic role in preventing the lung injury seen in endotoxaemia. Copyright © 2001 Taylor and Francis Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 1102-4151
eISSN: 1741-9271
DOI: 10.1080/110241501753171164
Titel-ID: cdi_proquest_miscellaneous_72286293
Format
–
Schlagworte
acute lung injury
,
Animals
,
ARDS
,
Biological and medical sciences
,
endotoxaemia
,
endotoxin
,
Endotoxins
,
Escherichia coli
,
Flow Cytometry
,
Hemodynamics - drug effects
,
Infusions, Intravenous
,
Lung - enzymology
,
Male
,
Medical sciences
,
Neutrophils - drug effects
,
Neutrophils - physiology
,
ovine model
,
Oxygen - blood
,
Peroxidase - metabolism
,
Pharmacology. Drug treatments
,
Pulmonary Artery
,
Respiratory Burst - drug effects
,
Respiratory Distress Syndrome, Adult - etiology
,
Respiratory Distress Syndrome, Adult - metabolism
,
Respiratory Distress Syndrome, Adult - physiopathology
,
Respiratory system
,
sepsis
,
Sheep
,
taurine
,
Taurine - administration & dosage
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