Details

Autor(en) / Beteiligte

• Peebles, R. Stokes
• Hashimoto, Koichi
• Collins, Robert D.
• Jarzecka, Kasia
• Furlong, Jamye
• Mitchell, Daphne B.
• Sheller, James R.
• Graham, Barney S.

Titel

Immune Interaction between Respiratory Syncytial Virus Infection and Allergen Sensitization Critically Depends on Timing of Challenges

Ist Teil von

• The Journal of infectious diseases, 2001-12, Vol.184 (11), p.1374-1379

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2001

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Severe respiratory syncytial virus (RSV) infection has been hypothesized to be a risk factor for the development of allergy and asthma, but epidemiologic studies in humans have been inconclusive. By use of a well-characterized murine model of RSV infection and allergic sensitization with ovalbumin, the effect of a preceding severe RSV infection on the development of the pulmonary allergic inflammatory response and airway hyperresponsiveness (AHR) was tested. The impact of prior allergic sensitization on RSV-induced illness, as measured by weight loss, also was evaluated. RSV infection before allergic sensitization decreased allergen-induced AHR, production of interleukin-13 in lung tissue, and lung eosinophilia. In contrast, allergic sensitization before RSV infection increased AHR and decreased RSV-related weight loss and lung levels of interferon-γ but did not alter viral clearance. These data provide evidence that RSV-associated AHR occurs in hosts with allergic responses and that allergic inflammation is diminished when preceded by RSV infection