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Endothelial Nitric Oxide Synthase Gene Sequence Variations and Vascular Disease
Ist Teil von
Molecular Genetics and Metabolism, 2000-08, Vol.70 (4), p.241-251
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2000
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Genes contribute significantly to interpopulation differences in vascular disease. Endothelial nitric oxide synthase (eNOS)—a key regulator of vascular nitric oxide production—has been investigated extensively to determine the relevance of DNA variants in the eNOS gene and vascular diseases. Variants in the promoter region, introns, and exons have been explored in a large number of populations but findings have been inconsistent. This paper reviews the current status of functional significance for reported sequence variations in the eNOS gene and the relevance of these variants to different forms of vascular diseases.