Details

Autor(en) / Beteiligte

• Fantuzzi, L
• Conti, L
• Gauzzi, M C
• Eid, P
• Del Corno, M
• Varano, B
• Canini, I
• Belardelli, F
• Gessani, S

Titel

Regulation of chemokine/cytokine network during in vitro differentiation and HIV-1 infection of human monocytes: possible importance in the pathogenesis of AIDS

Ist Teil von

• Journal of leukocyte biology, 2000-09, Vol.68 (3), p.391-399

Ort / Verlag

United States: Society for Leukocyte Biology

Erscheinungsjahr

2000

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• The monocyte/macrophage lineage represents heterogeneous cell populations characterized by major differences in the phenotype and functional activities. These cells are a major source of soluble factors, such as cytokines and chemokines, which can both affect HIV replication and AIDS pathogenesis. Although monocytes/macrophages are unanimously considered important targets of HIV‐1 infection, the HIV‐induced alterations in their physiological functions at different stages of differentiation are still matter of debate. In this article, we review our data on the regulation of chemokine/cytokine network with regard to macrophage differentiation and HIV‐1 infection, in comparison with studies from other groups. The ensemble of the results emphasizes that: 1) macrophages markedly differ with respect to monocytes for a variety of responses potentially important in the pathogenesis of HIV infection; and 2) the experimental conditions can influence the HIV‐monocyte/macrophage interactions, reflecting the possible in vivo existence of a spectrum of responses among macrophage populations.