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Kluyveromyces marxianus exhibits an ancestral Saccharomyces cerevisiae genome organization downstream of ADH2
Ist Teil von
Gene, 2000-09, Vol.255 (1), p.83-91
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2000
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
In
Saccharomyces cerevisiae, the alcohol dehydrogenase genes
ADH1 and
ADH5 are part of a duplicated block of genome, thought to originate from a genome-wide duplication posterior to the divergence from the
Kluyveromyces lineage. We report here the characterization of
Kluyveromyces marxianus ADH2 and the five genes found in its immediate downstream region,
MRPS9,
YOL087C,
RPB5,
RIB7 and
SPP381. The order of these six genes reflects the structure of the ancestral
S. cerevisiae genome before the duplication that formed the blocks including
ADH1 on chromosome XV and
ADH5 on chromosome II, indicating these
ADH genes share a direct ancestor. On the one hand, the two genes found immediately downstream of
KmADH2 are located, for the first, downstream
ADH5 and, for the second, downstream
ADH1 in
S. cerevisiae. On the other hand, the order of the paralogs included in the blocks of
ADH1 and
ADH5 in
S. cerevisiae suggests that two of them have been inverted within one block after its formation, and that inversion is confirmed by the gene order observed in
K. marxianus.