Details

Autor(en) / Beteiligte

• Miyashita, Yoh
• Ito, Yoshiaki
• Hasiguchi, Shoichiro
• Totsuka, Mitsuya
• Aoki, Akiko
• Kurokawa, Minoru
• Tomioka, Hisao
• Shirai, Kohji

Titel

Effect of Temocapril Hydrochloride on Serum Lipid Levels in Patients with Hypertensive Type 2 Diabetes Mellitus

Ist Teil von

• Journal of Atherosclerosis and Thrombosis, 2001, Vol.8(1), pp.25-29

Ort / Verlag

Japan: Japan Atherosclerosis Society

Erscheinungsjahr

2001

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The effect of angiotensin converting enzyme inhibitor, temocapril hydrochloride on the serum lipoproteins, and especially on the size of low density lipoproteins (LDL) of hypertensive diabetic patients, were studied. Temocapril hydrochloride (5 mg/day) was administered to 32 hypertensive type 2 diabetes patients for 16 weeks. During treatment, systolic and diastolic blood pressures decreased significantly from 162/95 mmHg to 138/76 mmHg at 16 weeks (p< 0.001), and serum levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) showed significant reduction, but those of HbA1c, triglycerides (TG) and high density lipoprotein cholesterol (HDL-C) showed no significant changes. LDL particle size evaluated by polyacrylamide gel disc electrophoresis was normalized from small size. It is concluded that temocapril hydrochloride favorably affects the serum lipoprotein metabolism of hypertensive type 2 dependent diabetes mellitus patients.