Details

Autor(en) / Beteiligte

• Xiao, Junhua
• Yuan, Gu
• Huang, Weiqiang
• Chan, Albert S. C
• Lee, K.-L. Daniel

Titel

A Convenient Method for the Synthesis of DNA-Recognizing Polyamides in Solution

Ist Teil von

• Journal of organic chemistry, 2000-09, Vol.65 (18), p.5506-5513

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2000

Quelle

MEDLINE

Beschreibungen/Notizen

• A convenient method for the synthesis of polyamides containing N-methylpyrrole (Py) and N-methylimidazole (Im) in solution has been developed. Most of the building blocks have been prepared by a haloform reaction in a simple way that column chromatography can be avoided. By use of the DCC/HOBT coupling reaction, the building blocks prepared have been effectively connected to construct a variety of subchains and polyamides without employing amino protection and deprotection. By use of the present method, an eight-ring polyamide, PyPyPyPyγPyImImPyβDp (γ is γ-aminobutyric acid, β is β-alanine, Dp is N,N-dimethylpropyldiamine), has been synthesized by the coupling of two four-ring subchains in one step.