Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (16), p.1863-1866
2000
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Details
- Autor(en) / Beteiligte
- Titel
- 1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines : Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (16), p.1863-1866
- Ort / Verlag
- Oxford: Elsevier
- Erscheinungsjahr
- 2000
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and their potential as novel non-sedating anxiolytic and antidepressants is under investigation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/S0960-894X(00)00364-4Titel-ID: cdi_proquest_miscellaneous_72224386
- Format
- –
- Schlagworte
- Administration, Oral, Aminopyridines - administration & dosage, Aminopyridines - chemical synthesis, Aminopyridines - chemistry, Aminopyridines - pharmacology, Animals, Anti-Anxiety Agents - administration & dosage, Anti-Anxiety Agents - chemical synthesis, Anti-Anxiety Agents - chemistry, Anti-Anxiety Agents - pharmacology, Antidepressive Agents - administration & dosage, Antidepressive Agents - chemical synthesis, Antidepressive Agents - chemistry, Antidepressive Agents - pharmacology, Biological and medical sciences, Drug Design, Humans, Indoles - administration & dosage, Indoles - chemical synthesis, Indoles - chemistry, Indoles - pharmacology, Kinetics, Medical sciences, Molecular Structure, Motor Activity - drug effects, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, Pharmacology. Drug treatments, Rats, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin - chemistry, Receptors, Serotonin - metabolism, Serotonin Antagonists - administration & dosage, Serotonin Antagonists - chemical synthesis, Serotonin Antagonists - chemistry, Serotonin Antagonists - pharmacology, Serotoninergic system, Structure-Activity Relationship