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Association analysis between mood disorder and monoamine oxidase gene
American journal of medical genetics, 2000-02, Vol.96 (1), p.12-14
Lin, Sicui
Jiang, Sanduo
Wu, Xiaodong
Qian, Yiping
Wang, Dongxiang
Tang, Guomei
Gu, Niufan
2000
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Lin, Sicui
Jiang, Sanduo
Wu, Xiaodong
Qian, Yiping
Wang, Dongxiang
Tang, Guomei
Gu, Niufan
Titel
Association analysis between mood disorder and monoamine oxidase gene
Ist Teil von
American journal of medical genetics, 2000-02, Vol.96 (1), p.12-14
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
2000
Quelle
MEDLINE
Beschreibungen/Notizen
To ascertain whether mood disorders, including bipolar and unipolar, are genetically associated with the monoamine oxidase A (MAOA) or monoamine oxidase B (MAOB) gene in the Chinese population, 132 cases of mood disorder and 88 normal controls were genotyped for the MAOA(CA)n, MAOB(GT)n, and MAOB(TG)n loci by the method of amplification fragment length polymorphism. Among 132 cases with mood disorder, eight alleles (size: 112–126 bp) of locus MAOA(CA)n, 12 alleles (size: 168–198 bp) of locus MAOB(GT)n, and nine alleles (size: 195–213 bp) of locus MAOB(TG)n were observed. Comparison of the allele frequency of the three loci showed no difference between mood disorder cases and normal controls on average. When each group was stratified into several subgroups, significant differences were found. On the MAOA(CA)n locus, the frequency of 116 bp allele was higher in the female bipolar disorder cases (0.2581) compared with that in the female unipolar disorder patients (0.1154) (Z=2.15, p<0.05). On the MAOB(GT)n locus, the frequency of 180 bp allele was higher in bipolar disorder patients (0.1579) than that in normal controls (0.0678) (Z=2.05, p<0.05). The frequency of this allele was even higher in female bipolar disorder patients (0.1719) than that in female normal controls (0.0541). On the MAOB(TG)n locus, the frequency of 205 bp allele was higher in female bipolar disorder patients (0.6406) than that in female normal controls (0.4375) (Z=2.17, p<0.05). For the unipolar disorder patients, the frequency of this allele was higher in female cases (0.5222) than that in male cases (0.1818) (Z=3.49, p<0.05). As for association studies, significant association between bipolar disorder and MAOB gene was detected. For the 180 bp allele of MAOB(GT)n, the relative risk (RR) of biploar versus normal control was 2.58 (p<0.05), and the RR of female bipolar disorder versus female normal control was 3.63 (p<0.05). For the 205 bp allele of MAOB(TG)n, the RR of female bipolar disorder versus female normal control was 2.29 (p<0.05). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:12–14, 2000. © 2000 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0148-7299
eISSN: 1096-8628
DOI: 10.1002/(SICI)1096-8628(20000207)96:1<12::AID-AJMG4>3.0.CO;2-S
Titel-ID: cdi_proquest_miscellaneous_72214306
Format
–
Schlagworte
Adult and adolescent clinical studies
,
Alleles
,
association
,
Base Sequence
,
Biological and medical sciences
,
Depression
,
DNA Primers
,
Female
,
Gene Frequency
,
Humans
,
Male
,
Medical genetics
,
Medical sciences
,
Mental and behavioral disorders
,
Microsatellite Repeats - genetics
,
Monoamine Oxidase - genetics
,
monoamine oxidase gene
,
mood disorder
,
Mood disorders
,
Mood Disorders - enzymology
,
Mood Disorders - genetics
,
Psychology. Psychoanalysis. Psychiatry
,
Psychopathology. Psychiatry
,
Tropical medicine
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