Cancer letters, 2000-10, Vol.158 (2), p.179-184
2000
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Details
- Autor(en) / Beteiligte
- Titel
- Correlation of telomere lengths in normal and cancers tissue in the large bowel
- Ist Teil von
- Cancer letters, 2000-10, Vol.158 (2), p.179-184
- Ort / Verlag
- Shannon: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2000
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- The hypothesis that telomeres in colorectal cancer cells exhibit age-related shortening, as in normal cells of the colorectal epithelium, was tested with samples of non-cancerous mucosa and cancer tissue from 124 patients (aged 29–97 years). Shortening with aging could be demonstrated for both normal and cancer tissues; regression analysis showed rates for length reduction of 44 and 50 base pair/year, respectively. Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/S0304-3835(00)00521-8Titel-ID: cdi_proquest_miscellaneous_72212532
- Format
- –
- Schlagworte
- Adult, Aged, Aged, 80 and over, Aging, Biological and medical sciences, Blotting, Southern, Colon carcinoma, Colorectal Neoplasms - genetics, Colorectal Neoplasms - pathology, DNA - genetics, DNA, Neoplasm - genetics, Female, Gastroenterology. Liver. Pancreas. Abdomen, Humans, Infant, Intestinal Mucosa - metabolism, Intestine, Large - metabolism, Large intestine, Male, Medical sciences, Middle Aged, Regression Analysis, Stomach. Duodenum. Small intestine. Colon. Rectum. Anus, Telomere - genetics, Telomere shortening, Tumors