Details

Autor(en) / Beteiligte

• Son, Li Zi
• Yanai, Kazuhiko
• Mobarakeh, Jalal Izadi
• Kuramasu, Atsuro
• Li, Zheng Yan
• Sakurai, Eiko
• Hashimoto, Yasuhiko
• Watanabe, Takeshi
• Watanabe, Takehiko

Titel

Histamine H1 receptor-mediated inhibition of potassium-evoked release of 5-hydroxytryptamine from mouse forebrains

Ist Teil von

• Behavioural brain research, 2001-10, Vol.124 (2), p.113-120

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2001

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The release of endogenous serotonin and dopamine from slices of mouse forebrains induced by high extracellular K + was examined in histamine H1 receptor knockout mice. The release of 5-hydroxytryptamine (5-HT) evoked by 30 mM K + significantly decreased in the presence of 10–50 μM histamine in wild-type mice, but was not inhibited in the mutant mice. Histamine H1 receptor-mediated inhibition of serotonin release in wild-type mice was also observed in the presence of thioperamide, an H3 antagonist. From these data, we postulate that endogenous histamine indirectly inhibits the release of 5-HT through H1 receptors in addition to H3 receptors. The treatment of 2 μM tetrodotoxin could partly abolish the effects of histamine on K +-evoked 5-HT release. Bicuculline, a GABA A antagonist, could reverse the histamine-induced inhibition of 5-HT release in wild-type mice, suggesting that H1 receptors facilitate the release of GABA, which in turn inhibits 5-HT release through GABA A receptors. The difference in the effects of d- and l-chlorpheniramine on K +-evoked 5-HT release in wild-type mice further supports the evidence of the function of H1 receptor modulating 5-HT release.