Oncogene, 2001-10, Vol.20 (44), p.6482-6491
2001
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- Autor(en) / Beteiligte
- Titel
- Tumor necrosis factor receptor-associated factors (TRAFs)
- Ist Teil von
- Oncogene, 2001-10, Vol.20 (44), p.6482-6491
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2001
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Tumor necrosis factor receptor-associated factors (TRAFS) were initially discovered as adaptor proteins that couple the tumor necrosis factor receptor family to signaling pathways. More recently they have also been shown to be signal transducers of Toll/interleukin-1 family members. Six members of the TRAF family have been identified. All TRAF proteins share a C-terminal homology region termed the TRAF domain that is capable of binding to the cytoplasmic domain of receptors, and to other TRAF proteins. In addition, TRAFs 2-6 have RING and zinc finger motifs that are important for signaling downstream events. TRAF proteins are thought to be important regulators of cell death and cellular responses to stress, and TRAF2, TRAF5 and TRAF6 have been demonstrated to mediate activation of NF-kappaB and JNK. TRAF proteins are expressed in normal and diseased tissue in a regulated fashion, suggesting that they play an important role in physiological and pathological processes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0950-9232eISSN: 1476-5594DOI: 10.1038/sj.onc.1204788Titel-ID: cdi_proquest_miscellaneous_72209833
- Format
- –
- Schlagworte
- Adaptor proteins, Amino Acid Motifs, Amino acids, Animals, Cell death, Cytokines, DNA binding proteins, Homology, Humans, Interleukin 1, Interleukin-1 - metabolism, Medicine, Necrosis, NF-κB protein, Physiological aspects, Protein Binding, Protein Structure, Tertiary, Proteins, Proteins - metabolism, Receptors, Tumor Necrosis Factor - chemistry, Receptors, Tumor Necrosis Factor - metabolism, Receptors, Tumor Necrosis Factor - physiology, Signal Transduction, TNF Receptor-Associated Factor 1, TNF Receptor-Associated Factor 2, TNF Receptor-Associated Factor 3, TNF Receptor-Associated Factor 4, TNF Receptor-Associated Factor 5, TNF Receptor-Associated Factor 6, TRAF protein, TRAF2 protein, TRAF6 protein, Transcription Factor AP-1 - metabolism, Tumor necrosis factor, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, Tumor necrosis factor-TNF, Tumors, Zinc finger proteins