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BibTeX
Multiple ephrins regulate hippocampal neurite outgrowth
Journal of comparative neurology (1911), 2000-09, Vol.425 (2), p.315-322
Brownlee, Heather
Gao, Pan-Pan
Frisen, Jonas
Dreyfus, Cheryl
Zhou, Renping
Black, Ira B.
2000
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Brownlee, Heather
Gao, Pan-Pan
Frisen, Jonas
Dreyfus, Cheryl
Zhou, Renping
Black, Ira B.
Titel
Multiple ephrins regulate hippocampal neurite outgrowth
Ist Teil von
Journal of comparative neurology (1911), 2000-09, Vol.425 (2), p.315-322
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
2000
Quelle
MEDLINE
Beschreibungen/Notizen
Increasing evidence indicates that the eph family of ligands and receptors guides the formation of topographic maps in the brain through repulsive interactions. For example, we have recently found that in the hippocamposeptal system, the ligand ephrin‐A2, which is expressed in an increasing gradient from dorsal to ventral septum, selectively induces pruning of topographically inappropriate medial hippocampal axons. The recent detection of ephrins A3 and A5, as well as A2, in the septum raised critical functional questions. Do the ligands act combinatorially, ensuring appropriate three‐dimensional spatiotemporal projection, or do they exert entirely distinct actions in addition to guidance mechanisms? To approach these alternatives, we cloned mouse ephrin‐A2 and compared the activities of the three ligands. Here, we show that these ligands reduce the number of hippocampal neurites in a similar fashion. The effect was regionally specific; medial hippocampal neurites were reduced 1.5‐ to 1.8‐fold, whereas lateral hippocampal neurites were not significantly affected, conforming to topographic projection in vivo. Furthermore, we found that ephrins regulated neurite number in a stage‐specific fashion, affecting E19 hippocampal neurites more than E16 neurites. Our observations suggest that all three septal ephrins, A2, A3, and A5, play spatiotemporally specific roles in guiding topographic projections from the hippocampus. J. Comp. Neurol. 425:315–322, 2000. © 2000 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9967
eISSN: 1096-9861
DOI: 10.1002/1096-9861(20000918)425:2<315::AID-CNE12>3.0.CO;2-#
Titel-ID: cdi_proquest_miscellaneous_72201567
Format
–
Schlagworte
Amino Acid Sequence
,
Animals
,
axon growth
,
Base Sequence
,
brain maps
,
Cells, Cultured
,
Cloning, Molecular - methods
,
cortex
,
eph
,
Ephrin-A2
,
Ephrin-A3
,
Ephrin-A5
,
ephrins
,
Female
,
Fetus
,
Gene Expression Regulation, Developmental - physiology
,
hippocampus
,
Hippocampus - cytology
,
Hippocampus - embryology
,
Hippocampus - metabolism
,
Membrane Proteins - genetics
,
Mice
,
Molecular Sequence Data
,
Neural Pathways - cytology
,
Neural Pathways - embryology
,
Neural Pathways - metabolism
,
Neurites - metabolism
,
Neurites - ultrastructure
,
Neurons - cytology
,
Neurons - metabolism
,
Pregnancy
,
Rats
,
Rats, Sprague-Dawley
,
Septal Nuclei - cytology
,
Septal Nuclei - embryology
,
Septal Nuclei - metabolism
,
septum
,
topographic projection
,
Transcription Factors - genetics
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