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Details

Autor(en) / Beteiligte
Titel
The LEW.1AR1/Ztm-iddm rat : a new model of spontaneous insulin-dependent diabetes mellitus
Ist Teil von
  • Diabetologia, 2001-09, Vol.44 (9), p.1189-1196
Ort / Verlag
Berlin: Springer
Erscheinungsjahr
2001
Quelle
SpringerLINK Contemporary (Konsortium Baden-Württemberg)
Beschreibungen/Notizen
  • We describe a new Type I (insulin-dependent) diabetes mellitus rat model (LEW.1AR1/Ztm-iddm) which arose through a spontaneous mutation in a congenic Lewis rat strain with a defined MHC haplotype (RT1.Aa B/Du Cu). The development of diabetes was characterised using biochemical, immunological and morphological methods. Diabetes appeared in the rats with an incidence of 20 % without major sex preference at 58+/-2 days. The disease was characterised by hyperglycaemia, glycosuria, ketonuria and polyuria. In peripheral blood, the proportion of T lymphocytes was in the normal range expressing the RT6.1 differentiation antigen. Islets were heavily infiltrated with B and T lymphocytes, macrophages and NK cells with beta cells rapidly destroyed through apoptosis in areas of insulitis. This Type I diabetic rat develops a spontaneous insulin-dependent autoimmune diabetes through beta cell apoptosis. It could prove to be a valuable new animal model for clarifying the mechanisms involved in the development of autoimmune diabetes.

Weiterführende Literatur

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