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Frequent expression of the Epstein-Barr virus (EBV)-induced gene, EBI3, an IL-12 p40-related cytokine, in Hodgkin and Reed-Sternberg cells
The Journal of pathology, 2002-11, Vol.198 (3), p.310-316
Niedobitek, Gerald
Päzolt, Doreen
Teichmann, Martina
Devergne, Odile
2002
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Niedobitek, Gerald
Päzolt, Doreen
Teichmann, Martina
Devergne, Odile
Titel
Frequent expression of the Epstein-Barr virus (EBV)-induced gene, EBI3, an IL-12 p40-related cytokine, in Hodgkin and Reed-Sternberg cells
Ist Teil von
The Journal of pathology, 2002-11, Vol.198 (3), p.310-316
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2002
Quelle
MEDLINE
Beschreibungen/Notizen
Epstein–Barr virus (EBV)‐associated Hodgkin lymphoma (HL) and nasopharyngeal carcinoma (NPC) usually occur in patients without clinically manifest deficiencies in anti‐viral immunity. In spite of expressing viral proteins, both tumours are apparently able to escape EBV‐specific immunity in vivo. EBI3 is an EBV‐induced cytokine homologous to the interleukin (IL)‐12 p40 subunit and can heterodimerize with IL‐12 p35. It has been suggested that EBI3 may function to antagonize IL‐12 and to inhibit the development of a Th1 immune response. EBI3 expression has been studied in tumour entities frequently associated with EBV infection to examine if EBI3 might contribute to local modulation of the immune response. It is shown that EBI3 is strongly expressed in Hodgkin and Reed–Sternberg cells in 32 of 33 HL cases, independently of the EBV status of the tumour cells. Furthermore, EBI3 expression was detected in the epithelial tumour cells of six of 40 NPC biopsies but not in Burkitt lymphomas. The results suggest that EBI3 may be an additional component of the repertoire employed by Hodgkin and Reed–Sternberg cells to inhibit an effective anti‐tumour or anti‐viral immune response. Copyright © 2002 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.1217
Titel-ID: cdi_proquest_miscellaneous_72165463
Format
–
Schlagworte
Burkitt lymphoma
,
Burkitt Lymphoma - immunology
,
Burkitt Lymphoma - metabolism
,
Burkitt Lymphoma - virology
,
EBI3
,
Epstein-Barr virus
,
Epstein-Barr Virus Infections - complications
,
Glycoproteins - metabolism
,
Herpesvirus 4, Human - isolation & purification
,
Hodgkin Disease - immunology
,
Hodgkin Disease - metabolism
,
Hodgkin Disease - virology
,
Hodgkin lymphoma
,
Humans
,
IL-12
,
Interleukin-12 - metabolism
,
Interleukin-12 Subunit p35
,
Interleukins
,
Minor Histocompatibility Antigens
,
nasopharyngeal carcinoma
,
Nasopharyngeal Neoplasms - immunology
,
Nasopharyngeal Neoplasms - metabolism
,
Nasopharyngeal Neoplasms - virology
,
Neoplasm Proteins - metabolism
,
Protein Subunits - metabolism
,
Receptors, Cytokine
,
Reed-Sternberg Cells - metabolism
,
Tumor Cells, Cultured
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