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Effects of three intravenous lipid emulsions on the survival and mononuclear phagocyte function of septic rats
Ist Teil von
Nutrition (Burbank, Los Angeles County, Calif.), 2002-09, Vol.18 (9), p.751-754
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
2002
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The immunosuppressive effects of intravenous lipid emulsions are a matter of great concern and debate. In a rat model of gram-negative bacteremia, we assessed whether the use of three intravenous lipid emulsions with different triacylglycerol compositions could influence mortality, bacterial clearance, and prostaglandin E
2 (PGE
2) levels and compared these groups with groups of orally fed rats and rats that received a small amount of calories in form of glucose without enteral feeding (starvation).
Rats were assigned to one of five groups: group 1 (control,
n = 15) received rodent chow ad libitum and saline infusion; group 2 (starvation group,
n = 12) had no access to chow and received an infusion of 5% glucose; group 3 (
n = 17) received total parenteral nutrition (TPN) with long-chain triacylglycerols; group 4 (
n = 12) received TPN with medium- and long-chain triacylglycerols; and group 5 (
n = 15) received TPN with its emulsion based on olive oil. Animals received isonitrogenous and isocaloric TPN. After 2 d of TPN, a dose of 10
8 colony-forming units of
Escherichia coli was introduced via the venous catheter; 2 d later the animals were killed. Blood, spleen, liver, and lungs were cultured. Circulating levels of PGE
2 were measured.
Bacterial growth in the liver and lungs were significantly higher in groups 3 and 4 than in group 1, with no differences among the other groups. Rates of bacteremia were significantly higher in groups 3 and 4 than in group 1, with no differences among the other groups. Plasma levels of PGE
2 did not differ, and mortality was unaffected.
Bacterial clearance clearly was preserved in orally fed, control rats when compared with rats on TPN with long-chain triacylglycerols or medium- plus long-chain triacylglycerols. However, the use of a lipid emulsion enriched intravenously with oleic acid was a valid way of reducing this disturbance, although plasma levels of PGE
2 and survival were not modified.