Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2935-2939
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2935-2939
- Ort / Verlag
- Oxford: Elsevier
- Erscheinungsjahr
- 2002
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- The structure-affinity relationships of two novel 2-substituted adenosine series containing a substituted pyrazole attached at the N-1 or C-4 position for the adenosine (ADO) A2A receptor are described. Compounds in the 2-(N-1-pyrazolyl) adenosine series IV provided the highest affinity for the ADO A2A receptor as compared to the 2-(C-4-pyrazolyl) series V. The main structural differences between the two series point to the N-1 nitrogen of series IV imparting more favorable binding interactions with the receptor than those of series V.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/S0960-894X(02)00609-1Titel-ID: cdi_proquest_miscellaneous_72118479
- Format
- –
- Schlagworte
- Adenosine - analogs & derivatives, Adenosine - chemical synthesis, Adenosine - pharmacology, Antianginal agents. Coronary vasodilator agents, Binding Sites, Biological and medical sciences, Cardiovascular system, Humans, Medical sciences, Models, Molecular, Molecular Conformation, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems, Pharmacology. Drug treatments, Purinergic P1 Receptor Antagonists, Receptor, Adenosine A2A, Structure-Activity Relationship, Vasodilator Agents - chemical synthesis, Vasodilator Agents - pharmacology