Details

Autor(en) / Beteiligte

• Wiedemann, Frank
• Link, Ralf
• Pumpe, Konrad
• Jacobshagen, Ulrich
• Schaefer, Hans E.
• Wiesmüller, Karl-Heinz
• Hummel, Rolf-Peter
• Jung, Günther
• Bessler, Wolfgang
• Böltz, Traudel

Titel

Histopathological studies on the local reactions induced by complete fReund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates

Ist Teil von

• The Journal of pathology, 1991-07, Vol.164 (3), p.265-271

Ort / Verlag

Chichester, UK: John Wiley & Sons, Ltd

Erscheinungsjahr

1991

Quelle

MEDLINE

Beschreibungen/Notizen

• The inflammatory reactions following subcutaneous application of adjuvants revealed characteristic pathological patterns. The injection of complete Freund's adjuvant (CFA) resulted in the formation of large lipid deposits encircled by an inflammatory reaction and concentrically arranged collagen bundles. Bacterial lipopolysaccharide (LPS) caused granulomatous aggregations of mononuclear cells with thrombotic vessel occlusions. Inoculation of the lipopeptide adjuvants induced accumulation of mononculear cells with only minimal fibrotic changes which were resolved after day 28. Lipopeptide conjugates based on the head group tripalmitoyl‐S‐glyceryl‐cysteinyl‐serin (P3CS) can thus be used as effective immunogens and adjuvants without long‐term tissue damage.