Details

Autor(en) / Beteiligte

• CHARBON, J. L
• SPÄHNI, M
• WICKI, P
• PFISTER, K

Titel

Cellular reactions in the small intestine of rats after infection with Fasciola hepatica

Ist Teil von

• Parasitology research (1987), 1991-01, Vol.77 (5), p.425-429

Ort / Verlag

Berlin: Springer

Erscheinungsjahr

1991

Quelle

2022 ECC(Springer)

Beschreibungen/Notizen

• Groups of five rats each were infected with metacercariae of Fasciola hepatica according to two experimental procedures. In the first experiment, they received 20 metacercariae 0, 1, 2 or 3 times at intervals of 4 weeks. In the second, both the inoculation dose and the interval between doses were varied. After the animals had been killed, the small intestine was prepared for histology and tissue sections were stained for the detection and quantification of mucosal mast cells (MMCs), eosinophils and goblet cells. The density of eosinophils and MMCs increased significantly with each reinfection in the first experiment; in the second, the MMC reaction reached a peak at 4 weeks post-infection (p.i.), whereas the eosinophils peaked at 4 and 17 weeks p.i. In addition, the reaction of these cells depended on the infectious dose. In both experiments, goblet cells reacted only weakly. These findings thus clearly reflect a considerable intestinal response against migrating juvenile F. hepatica. The pattern of these defence reactions in the small intestine suggests some similarities with the mechanisms of antibody-dependent cell-mediated cytotoxicity that have been shown to take place during Schistosoma mansoni reinfection.