Gene therapy, 2002-09, Vol.9 (18), p.1221-1229
2002
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Details
- Autor(en) / Beteiligte
- Titel
- Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model
- Ist Teil von
- Gene therapy, 2002-09, Vol.9 (18), p.1221-1229
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2002
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Atopic dermatitis, a chronic inflammatory skin disease characterized by relapsing eczema and intense prurigo, requires effective and safe pharmacological therapy. In this study, we examined the efficacy of ointment containing NF-kB decoy oligodeoxynucleotides (ODN) on atopic dermatitis lesions in NC/Nga mice, which are characterized by the spontaneous onset of atopic dermatitis in conventional conditions. Topical administration of NF-kB decoy ODN twice a month resulted in a significant reduction in clinical skin condition score and marked improvement of histological findings. Reduction of the atopic skin condition by NF-kB decoy ODN was accompanied by a significant decrease in migration of mast cells into the dermis and an increase in apoptotic cells. Here, we demonstrated the successful treatment of atopic dermatitis with ointment containing NF-kB decoy ODN in a mouse model, promising new therapy for atopic dermatitis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0969-7128eISSN: 1476-5462DOI: 10.1038/sj.gt.3301724Titel-ID: cdi_proquest_miscellaneous_72066982
- Format
- –
- Schlagworte
- Administration, Cutaneous, Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Animals, Apoptosis, Applied cell therapy and gene therapy, Atopic dermatitis, Biological and medical sciences, Biotechnology, Cell migration, Dermatitis, Dermatitis, Atopic - immunology, Dermatitis, Atopic - therapy, Dermis, Eczema, Fundamental and applied biological sciences. Psychology, Gene therapy, Genetic Therapy - methods, Health. Pharmaceutical industry, In Situ Nick-End Labeling, Industrial applications and implications. Economical aspects, Male, Mast cells, Mast Cells - pathology, Medical sciences, Mice, Mice, Inbred Strains, Models, Animal, NF-kappa B - genetics, NF-κB protein, Ointments, Oligonucleotides, Skin Absorption, Skin diseases, Transfection - methods, Transfusions. Complications. Transfusion reactions. Cell and gene therapy