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Genetic heterogeneity of the envelope 2 gene and eradication of hepatitis C virus after a second course of interferon-α
Journal of medical virology, 2002-10, Vol.68 (2), p.221-228
Boulestin, Anne
Sandres-Sauné, Karine
Payen, Jean-Louis
Alric, Laurent
Dubois, Martine
Pasquier, Christophe
Vinel, Jean-Pierre
Pascal, Jean-Pierre
Puel, Jacqueline
Izopet, Jacques
2002
Details
Autor(en) / Beteiligte
Boulestin, Anne
Sandres-Sauné, Karine
Payen, Jean-Louis
Alric, Laurent
Dubois, Martine
Pasquier, Christophe
Vinel, Jean-Pierre
Pascal, Jean-Pierre
Puel, Jacqueline
Izopet, Jacques
Titel
Genetic heterogeneity of the envelope 2 gene and eradication of hepatitis C virus after a second course of interferon-α
Ist Teil von
Journal of medical virology, 2002-10, Vol.68 (2), p.221-228
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2002
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
The heterogeneity of the envelope 2 (E2) gene of the hepatitis C virus (HCV) was involved in the sensitivity of HCV to interferon‐α (IFN‐α). To assess the factors leading to virus eradication by IFN‐α, patients whose first treatment by IFN‐α failed and who had virus eradication after a second treatment were studied. These patients were paired with subjects in whom both treatments failed. The phosphorylation homology domain of the E2 gene (E2‐PHD) had no sequence variation between the two stages in both groups of patients. Therefore, this region has no clinical predictive value within a specific genotype. The hypervariable region 1 (HVR1) was analyzed by cloning and sequencing 20 clones per sample. Comparison of samples showed that the change in quasispecies induced by the first IFN‐α therapy could be associated with virus elimination obtained after a second treatment. The greater proportion of nonsynonymous mutations that was noted before the second treatment in responders suggest that pretherapeutic immune response is a major factor determining virus elimination and that the immune status of these patients changed between the first and the second treatment. J. Med. Virol. 68:221–228, 2002. © 2002 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.10192
Titel-ID: cdi_proquest_miscellaneous_72060240
Format
–
Schlagworte
Adult
,
Aged
,
Amino Acid Sequence
,
Bacteriology
,
Base Sequence
,
Biological and medical sciences
,
DNA, Viral - genetics
,
E2-PHD
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Genes, env
,
Genetic Variation
,
Genetics
,
HCV
,
Hepacivirus - drug effects
,
Hepacivirus - genetics
,
Hepatitis C, Chronic - drug therapy
,
Hepatitis C, Chronic - immunology
,
Hepatitis C, Chronic - virology
,
Humans
,
HVR1
,
IFN-α
,
Interferon Type I - therapeutic use
,
Male
,
Microbiology
,
Middle Aged
,
Molecular Sequence Data
,
Mutation
,
Recombinant Proteins
,
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
,
Retrospective Studies
,
Sequence Homology, Amino Acid
,
Treatment Failure
,
Viral Envelope Proteins - genetics
,
Viral Proteins - genetics
,
Virology
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