Details

Autor(en) / Beteiligte

• Lim, Seng G.
• Lee, Christine A.
• Charman, Heather
• Tilsed, Gillian
• Griffiths, Paul D.
• Kernoff, Peter B. A.

Titel

Hepatitis C antibody assay in a longitudinal study of haemophiliacs

Ist Teil von

• British journal of haematology, 1991-07, Vol.78 (3), p.398-402

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1991

Quelle

MEDLINE

Beschreibungen/Notizen

• Stored sera from 28 patients with inherited coagulation disorders who had developed non‐A non‐B hepatitis (NANBH) following a first exposure to clotting factor concentrates and 15 similar, but unmatched, patients who had received blood products but had normal transaminases on sequential testing were tested using the Ortho enzyme‐linked immunosorbent assay (ELISA) anti‐HCV assay. Twenty‐seven of the 28 patients with NANBH were anti‐HCV positive after exposure. In 10 of those in whom dates of first exposure and seroconversion were well‐defined, the median time interval to NANBH was 4 weeks (range 1–7) and to anti‐HCV seroconversion was 11 weeks (range 7·5–14·5). None of the 15 patients without NANBH developed anti‐HCV. This first generation Ortho ELISA anti‐HCV assay showed 96% sensitivity and 100% specificity and has potential use as an adjunct in the surveillance of new clotting factor products.