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Against which human papillomavirus types shall we vaccinate and screen? the international perspective
International journal of cancer, 2004-08, Vol.111 (2), p.278-285
Muñoz, Nubia
Bosch, F. Xavier
Castellsagué, Xavier
Díaz, Mireia
de Sanjose, Silvia
Hammouda, Doudja
Shah, Keerti V.
Meijer, Chris J.L.M.
2004
Volltextzugriff (PDF)
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Autor(en) / Beteiligte
Muñoz, Nubia
Bosch, F. Xavier
Castellsagué, Xavier
Díaz, Mireia
de Sanjose, Silvia
Hammouda, Doudja
Shah, Keerti V.
Meijer, Chris J.L.M.
Titel
Against which human papillomavirus types shall we vaccinate and screen? the international perspective
Ist Teil von
International journal of cancer, 2004-08, Vol.111 (2), p.278-285
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2004
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
At least 15 types of HPV have been associated with cervical cancer, but current HPV vaccines confer only type‐specific immunity. To determine geographic variations in the HPV type distribution in cervical cancer, we carried out a pooled analysis of data from an international survey of HPV types in cervical cancer and from a multicenter case‐control study, both co‐coordinated by the IARC. Study cases were 3,607 women with incident, histologically confirmed cervical cancer recruited in 25 countries. HPV DNA detection and typing in cervical cells or biopsies were centrally done using PCR assays. Estimates of the potential number of cases prevented by HPV type‐specific vaccines and changes in the validity of different HPV screening cocktails were calculated. HPV DNA was detected in 96% of specimens, and 30 different types were detected. The 15 most common types were, in descending order of frequency, 16, 18, 45, 31, 33, 52, 58, 35, 59, 56, 39, 51, 73, 68 and 66. Higher than average proportions of type 16 were found in northern Africa, of type 18 in south Asia, of type 45 in sub‐Saharan Africa and of type 31 in Central/South America. A vaccine including types 16 and 18 could potentially prevent 71% of cervical cancers worldwide, but its impact with regard to the percentage of cases potentially prevented would be higher in Asia and Europe/North America. In contrast, a vaccine containing the 7 most common HPV types would prevent about 87% of cervical cancers worldwide, with little regional variation. The impact of modifying the number of types in the screening cocktail tests would be small and probably irrelevant for screening programs. © 2004 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.20244
Titel-ID: cdi_proquest_miscellaneous_72024979
Format
–
Schlagworte
Africa
,
Biological and medical sciences
,
Case-Control Studies
,
cervical cancer
,
DNA, Viral - analysis
,
DNA, Viral - classification
,
Europe
,
Female
,
Female genital diseases
,
Geography
,
Gynecology. Andrology. Obstetrics
,
Health Surveys
,
Human papillomavirus
,
human papillomavirus geographic distribution
,
Humans
,
International Cooperation
,
Mass Screening
,
Medical sciences
,
North America
,
Papillomaviridae - immunology
,
Papillomaviridae - pathogenicity
,
Papillomavirus Infections - complications
,
Papillomavirus Infections - diagnosis
,
Papillomavirus Infections - prevention & control
,
South America
,
Tropical medicine
,
Tumors
,
Uterine Cervical Neoplasms - prevention & control
,
Uterine Cervical Neoplasms - virology
,
Viral Vaccines
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