Circulation (New York, N.Y.), 2004-06, Vol.109 (23 Suppl 1), p.III8-II14
2004
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Details
- Autor(en) / Beteiligte
- Titel
- HDL cholesterol and protective factors in atherosclerosis
- Ist Teil von
- Circulation (New York, N.Y.), 2004-06, Vol.109 (23 Suppl 1), p.III8-II14
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C levels are linked to rates of coronary events. The cardioprotective effects of HDL-C have been attributed to its role in reverse cholesterol transport, its effects on endothelial cells, and its antioxidant activity. Although some clinical trials suggest a benefit of raising HDL-C to reduce risk, further studies are needed, and HDL-C is still not considered a primary target of therapy in the National Cholesterol Education Program guidelines. However, HDL-C should be considered as part of the patient's overall profile of established risk factors in determining treatment strategies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-7322eISSN: 1524-4539DOI: 10.1161/01.CIR.0000131512.50667.46Titel-ID: cdi_proquest_miscellaneous_72022535
- Format
- –
- Schlagworte
- Adult, Aged, Animals, Arteriosclerosis - blood, Arteriosclerosis - epidemiology, Arteriosclerosis - etiology, Arteriosclerosis - prevention & control, ATP Binding Cassette Transporter 1, ATP-Binding Cassette Transporters - genetics, ATP-Binding Cassette Transporters - metabolism, Biological Transport, Cholesterol - metabolism, Cholesterol, HDL - blood, Cholesterol, HDL - chemistry, Cholesterol, HDL - physiology, Disease Susceptibility, Endothelium, Vascular - physiopathology, Female, Humans, Hyperlipidemias - blood, Hyperlipidemias - complications, Hyperlipidemias - genetics, Hypolipidemic Agents - pharmacology, Hypolipidemic Agents - therapeutic use, Liver - metabolism, Male, Membrane Lipids - metabolism, Mice, Mice, Transgenic, Middle Aged, Oxidation-Reduction, Randomized Controlled Trials as Topic, Risk Factors