Details

Autor(en) / Beteiligte

• Nekrutenko, Anton

Titel

Reconciling the numbers: ESTs versus protein-coding genes

Ist Teil von

• Molecular biology and evolution, 2004-07, Vol.21 (7), p.1278-1282

Ort / Verlag

United States

Erscheinungsjahr

2004

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The number of expressed sequences greatly surpasses the estimated number of protein-coding genes in mammalian genomes. An evolutionary approach reveals that only 9% to 14% of human-expressed and mouse-expressed sequences are able to code for proteins. Clustering of these sequences using cross-species relationships suggests that millions of expressed sequences may correspond to only approximately 20,000 distinct protein-coding transcripts.