Details

Autor(en) / Beteiligte

• Motamedi, Gholam K.
• Lesser, Ronald P.
• Miglioretti, Diana L.
• Mizuno‐Matsumoto, Yuko
• Gordon, Barry
• Webber, William R. S.
• Jackson, Darryl C.
• Sepkuty, Jehuda P.
• Crone, Nathan E.

Titel

Optimizing Parameters for Terminating Cortical Afterdischarges with Pulse Stimulation

Ist Teil von

• Epilepsia (Copenhagen), 2002-08, Vol.43 (8), p.836-846

Ort / Verlag

Boston, MA, USA: Blackwell Science Inc

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. Methods: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. Results: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). Conclusions: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.