Biological and Pharmaceutical Bulletin, 2004, Vol.27(6), pp.835-837
2004
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Estrogenic and Anti-androgenic Activity of Nitrophenols in Diesel Exhaust Particles (DEP)
- Ist Teil von
- Biological and Pharmaceutical Bulletin, 2004, Vol.27(6), pp.835-837
- Ort / Verlag
- Japan: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We recently isolated 4-nitrophenol, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenol, and 4-nitro-3-phenylphenol from diesel exhaust particles (DEP) and identified them as vasodilators. Because these compounds are alkylphenolic derivatives that might mimic hormones, we evaluated their estrogenic activity by human estrogen receptor (hER)-yeast screen assay. All of these nitrophenol derivatives except 2-methyl-4-nitrophenol exhibited estrogenic activity. Some estrogenic compounds are also anti-androgenic, so we measured the anti-androgenic activity of the same compounds by human androgen receptor (hAR)-yeast screen assay. We found anti-androgenicity in all four nitrophenols. Nitrophenols in DEP possess not only vasodilatory activity but also estrogenic and anti-androgenic activity.
- Sprache
- Englisch; Japanisch
- Identifikatoren
- ISSN: 0918-6158eISSN: 1347-5215DOI: 10.1248/bpb.27.835Titel-ID: cdi_proquest_miscellaneous_72003573
- Format
- –
- Schlagworte
- Androgen Receptor Antagonists, Androgens - metabolism, anti-androgenic activity, diesel exhaust particle, Dose-Response Relationship, Drug, estrogenic activity, Estrogens - pharmacology, Hormone Antagonists - pharmacology, Humans, nitrophenol, Nitrophenols - pharmacology, Receptors, Androgen - metabolism, Receptors, Estrogen - metabolism, Vehicle Emissions - adverse effects, Yeasts - drug effects, Yeasts - metabolism