Details

Autor(en) / Beteiligte

• Arai, Yoshitsugu
• Kasai, Makoto
• Masaki, Yukio

Titel

Synthesis of Chiral Sulfinyl-Substituted 1-Indolyl Enones and Asymmetric Conjugate Addition by an Arylcopper Reagent

Ist Teil von

• Chemical and Pharmaceutical Bulletin, 2004, Vol.52(6), pp.733-738

Ort / Verlag

Japan: The Pharmaceutical Society of Japan

Erscheinungsjahr

2004

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• The asymmetric conjugate addition of arylcopper reagents to chiral 1-[2-(p-tolylsulfinyl)]indolyl and 1-[3-(p-tolylsulfinyl)]indolyl enones was examined. With the 2-sulfinyl-indolyl derivatives, the reaction of the arylcopper reagent gave high diastereoselectivities (81—88% de's) to afford the adducts in excellent yields, although the similar addition reaction of the 3-sulfinyl derivatives afforded poor diastereoselectivities.