Details

Autor(en) / Beteiligte

• Karkar, Kameel M.
• Garcia, Paul A.
• Bateman, Lisa M.
• Smyth, Matthew D.
• Barbaro, Nicholas M.
• Berger, Mitchel

Titel

Focal Cooling Suppresses Spontaneous Epileptiform Activity without Changing the Cortical Motor Threshold

Ist Teil von

• Epilepsia (Copenhagen), 2002-08, Vol.43 (8), p.932-935

Ort / Verlag

Boston, MA, USA: Blackwell Science Inc

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose: Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans. Methods: Electrocorticography was performed before resection of a right frontal tumor in a patient with partial seizures. Cold saline was applied to the interictal spike focus, and its effect on the epileptiform discharges was observed. Results: Application of cold saline to the spike focus resulted in a transient, complete cessation of spiking. This effect was reproduced with a second application of cold saline. The motor threshold for electrical stimulation remained unchanged during the application of saline. Conclusions: In this patient with tumor‐related epilepsy, focal cooling of the cortex reproducibly abolished interictal epileptiform discharges without changing the motor threshold to electrical stimulation.