Details

Autor(en) / Beteiligte

• Muttukrishna, S
• Jauniaux, E
• McGarrigle, H
• Groome, N
• Rodeck, CH

Titel

In-vivo concentrations of inhibins, activin A and follistatin in human early pregnancy

Ist Teil von

• Reproductive biomedicine online, 2004, Vol.8 (6), p.712-719

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• The aims of this study were to investigate the relationship between inhibins, activin A and follistatin in first trimester fetal fluids, maternal serum, placenta and decidua, and to investigate if these hormones are present in the circulation of the early second trimester human fetus. Amniotic and coelomic fluid, maternal serum, placental villi and decidual tissue were obtained from normal pregnancies at 8–12 weeks. Fetal blood by cardiocentesis and maternal blood were collected at 14–16 weeks gestation. Placental extracts had higher concentrations of inhibins, activin A and follistatin compared with decidual extracts. In the second trimester, inhibins and follistatin were detectable in fetal blood at 14–16 weeks gestation. Maternal serum concentrations of inhibin A ( P < 0.001) and follistatin ( P < 0.05) were significantly higher than fetal serum whereas inhibin B ( P < 0.01) and pro-alpha C concentrations ( P < 0.001) were higher in fetal serum. Inhibin B concentrations were also higher in male fetal serum samples that had higher concentrations of testosterone. The presence of all molecular forms of inhibins, activin A and follistatin in the first trimester fetal fluids, placental and decidual extracts in the first trimester confirms other reports. In the second trimester, high concentrations of inhibin B with testosterone in the fetal circulation indicate that these hormones may interact in the development of the male fetal gonads.