Details

Autor(en) / Beteiligte

• Ebers, GC
• Sadovnick, AD
• Dyment, DA
• Yee, IML
• Willer, CJ
• Risch, Neil

Titel

Parent-of-origin effect in multiple sclerosis: observations in half-siblings

Ist Teil von

• The Lancet (British edition), 2004-05, Vol.363 (9423), p.1773-1774

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2004

Quelle

Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• Multiple sclerosis is a complex trait in which occurrence rates in offspring are 20–50-fold greater than in the general population. Parent-of-origin effects have been difficult to screen for, since most cases are sporadic. We have compared recurrence risks in half-siblings with respect to their parent in common. Of the 1567 index cases with half-siblings in multiple sclerosis clinics across Canada, we recorded 3436 half-siblings and 2706 full-siblings. Age-adjusted full-sibling risk was 3·11%. By contrast, half-sibling risk in the same families was significantly lower at 1·89% χ2 test, p=0·006), but higher than expected if familial risk was simply polygenic. For maternal half-siblings, the risk was 2·35% (34 affected siblings of 1859), and 1·31% for paternal half-siblings (15 of 1577), (p=0·048). The difference in risk suggests a maternal parent-of-origin effect in multiple sclerosis susceptibility.