UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 17 von 27
Datensatz exportieren als...
BibTeX
Prevalence of familial pancreatic cancer in Germany
International journal of cancer, 2004-07, Vol.110 (6), p.902-906
Bartsch, Detlef K.
Kress, Ralf
Sina‐Frey, Mercedes
Grützmann, Robert
Gerdes, Berthold
Pilarsky, Christian
Heise, Joachim W.
Schulte, Klaus‐Martin
Colombo‐Benkmann, Mario
Schleicher, Cristina
Witzigmann, Helmut
Pridöhl, Olaf
Ghadimi, Michael B.
Horstmann, Olaf
von Bernstorff, Wolfgang
Jochimsen, Lisa
Schmidt, Jan
Eisold, Sven
Estévéz‐Schwarz, Lope
Hahn, Stephan A.
Schulmann, Karsten
Böck, Wolfgang
Gress, Thomas M.
Zügel, Nikolaus
Breitschaft, Karl
Prenzel, Klaus
Messmann, Helmut
Endlicher, Esther
Schneider, Margarete
Ziegler, Andreas
Schmiegel, Wolff
Schäfer, Helmut
Rothmund, Matthias
Rieder, Harald
2004
Details
Autor(en) / Beteiligte
Bartsch, Detlef K.
Kress, Ralf
Sina‐Frey, Mercedes
Grützmann, Robert
Gerdes, Berthold
Pilarsky, Christian
Heise, Joachim W.
Schulte, Klaus‐Martin
Colombo‐Benkmann, Mario
Schleicher, Cristina
Witzigmann, Helmut
Pridöhl, Olaf
Ghadimi, Michael B.
Horstmann, Olaf
von Bernstorff, Wolfgang
Jochimsen, Lisa
Schmidt, Jan
Eisold, Sven
Estévéz‐Schwarz, Lope
Hahn, Stephan A.
Schulmann, Karsten
Böck, Wolfgang
Gress, Thomas M.
Zügel, Nikolaus
Breitschaft, Karl
Prenzel, Klaus
Messmann, Helmut
Endlicher, Esther
Schneider, Margarete
Ziegler, Andreas
Schmiegel, Wolff
Schäfer, Helmut
Rothmund, Matthias
Rieder, Harald
Titel
Prevalence of familial pancreatic cancer in Germany
Ist Teil von
International journal of cancer, 2004-07, Vol.110 (6), p.902-906
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2004
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Based on several case‐control studies, it has been estimated that familial aggregation and genetic susceptibility play a role in up to 10% of patients with pancreatic cancer, although conclusive epidemiologic data are still lacking. Therefore, we evaluated the prevalence of familial pancreatic cancer and differences to its sporadic form in a prospective multicenter trial. A total of 479 consecutive patients with newly diagnosed, histologically confirmed adenocarcinoma of the pancreas were prospectively evaluated regarding medical and family history, treatment and pathology of the tumour. A family history for pancreatic cancer was confirmed whenever possible by reviewing the tumour specimens and medical reports. Statistical analysis was performed by calculating odds ratios, regression analysis with a logit‐model and the Kaplan‐Meier method. Twenty‐three of 479 (prevalence 4.8%, 95% CI 3.1–7.1) patients reported at least 1 first‐degree relative with pancreatic cancer. The familial aggregation could be confirmed by histology in 5 of 23 patients (1.1%, 95% CI 0.3–2.4), by medical records in 9 of 23 patients (1.9%, 95% CI 0.9–3.5) and by standardized interviews of first‐degree relatives in 17 of 23 patients (3.5%, 95% CI 2.1–5.6), respectively. There were no statistical significant differences between familial and sporadic pancreatic cancer cases regarding sex ratio, age of onset, presence of diabetes mellitus and pancreatitis, tumour histology and stage, prognosis after palliative or curative treatment as well as associated tumours in index patients and families, respectively. The prevalence of familial pancreatic cancer in Germany is at most 3.5% (range 1.1–3.5%) depending on the mode of confirmation of the pancreatic carcinoma in relatives. This prevalence is lower than so far postulated in the literature. There were no significant clinical differences between the familial and sporadic form of pancreatic cancer. © 2004 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.20210
Titel-ID: cdi_proquest_miscellaneous_71969153
Format
–
Schlagworte
Adult
,
Aged
,
Biological and medical sciences
,
epidemiology
,
familial pancreatic cancer
,
Family
,
Female
,
Gastroenterology. Liver. Pancreas. Abdomen
,
Genetic Predisposition to Disease - genetics
,
Germany - epidemiology
,
Humans
,
Liver. Biliary tract. Portal circulation. Exocrine pancreas
,
Male
,
Medical Records
,
Medical sciences
,
Middle Aged
,
Odds Ratio
,
Pancreatic Neoplasms - epidemiology
,
Pancreatic Neoplasms - genetics
,
Pancreatic Neoplasms - pathology
,
Prevalence
,
Retrospective Studies
,
Tumors
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX