Details

Autor(en) / Beteiligte

• LAHLOU, HICHAM
• GUILLERMET, JULIE
• HORTALA, MARYLIS
• VERNEJOUL, FABIENNE
• PYRONNET, STÉPHANE
• BOUSQUET, CORINNE
• SUSINI, CHRISTIANE

Titel

Molecular Signaling of Somatostatin Receptors

Ist Teil von

• Annals of the New York Academy of Sciences, 2004-04, Vol.1014 (1), p.121-131

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2004

Link zum Volltext

Quelle

Wiley HSS Collection

Beschreibungen/Notizen

• : Somatostatin is a neuropeptide family that is produced by neuroendocrine, inflammatory, and immune cells in response to different stimuli. Somatostatin acts as an endogenous inhibitory regulator of various cellular functions including secretions, motility, and proliferation. Its action is mediated by a family of G‐protein‐coupled receptors (called sst1‐sst5) that are widely distributed in the brain and periphery. The five receptors bind the natural peptides with high affinity, but only sst2, sst5, and sst3 bind the short synthetic analogs used to treat acromegaly and neuroendocrine tumors. This review covers the current knowledge in somatostatin receptor biology and signaling.