Details

Autor(en) / Beteiligte

• SORIANO, Vincent
• PEREZ-OLMEDA, Mayte
• RIOS, Pilar
• NUNEZ, Marina
• GARCIA-SAMANIEGO, Javier
• GONZALEZ-LAHOZ, Juan

Titel

Hepatitis C virus (HCV) relapses after anti-HCV therapy are more frequent in HIV-infected patients

Ist Teil von

• AIDS research and human retroviruses, 2004-04, Vol.20 (4), p.351-353

Ort / Verlag

Larchmont, NY: Liebert

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• The response to standard or pegylated interferon (IFN) plus ribavirin (RBV) seems to be lower in hepatitis C virus (HCV)/HIV-coinfected subjects than in HCV-monoinfected patients. Thus, the principles guiding anti-HCV therapy in HIV-negative patients may not apply in the setting of HIV infection. We examined the rate of HCV relapse in 58 HCV/HIV-coinfected subjects who showed undetectable HCV-RNA (<600 IU/ml) at the end of anti-HCV combination therapy. Overall, 19 (32.8%) patients relapsed after discontinuing treatment, a rate significantly higher than that seen in HIV negatives, which is in the range of 15-20%. There were no significant differences between HCV genotypes (33.3% for HCV genotypes 2-3 versus 31.8% for HCV genotypes 1-4) and/or the use of either standard or pegylated IFN (37% versus 29%, respectively). Thus, extended periods of anti-HCV therapy might reduce HCV relapses in HIV-coinfected patients initially responding to therapy.