Details

Autor(en) / Beteiligte

• Li, Da Wei
• Lee, Eun Bang
• Kang, Sam Sik
• Hyun, Jin Ee
• Whang, Wan Kyun

Titel

Activity-Guided Isolation of Saponins from Kalopanax pictus with Anti-inflammatory Activity

Ist Teil von

• Chemical and Pharmaceutical Bulletin, 2002, Vol.50(7), pp.900-903

Ort / Verlag

Tokyo: The Pharmaceutical Society of Japan

Erscheinungsjahr

2002

Quelle

MEDLINE

Beschreibungen/Notizen

• By bioassay-guided separation, a known saponin, kalopanaxsaponin A (1) and a new saponin, pictoside A (2) were isolated from the stem bark of Kalopanax pictus as anti-inflammatory components when evaluated by vascular permeability test. Another novel saponin, pictoside B (3) was also isolated but was inactive in the test system used. The structures of pictosides A and B were elucidated as caulophyllogenin 3-O-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranoside (2) and pictogenin (3β,6β,16α,23-tetrahydroxyolean-12-ene-28-oic acid) 3-O-α-L-arabinopyranoside (3), respectively, by spectral analysis and by chemical degradation. Kalopanaxsaponin A and pictoside A showed significant anti-inflammatory activity at the oral doses of 50 mg/kg.