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Correlation between tumor necrosis factor-alpha and d-dimer levels in non-small cell lung cancer patients
Ist Teil von
Lung cancer (Amsterdam, Netherlands), 2004-06, Vol.44 (3), p.303-310
Ort / Verlag
Shannon: Elsevier Ireland Ltd
Erscheinungsjahr
2004
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The present study was designed to investigate whether a correlation exists between IL-6, TNF-α and coagulation (Thrombin–antithrombin, TATc) or fibrinolysis (
d-dimer) activation in non-small cell lung cancer (NSCLC) patients. One hundred thirty patients with NSCLC (
n=65, 53 males, mean age 65±8, adenocarcinoma
n=32, squamous cancer
n=33) or chronic obstructive pulmonary disease (COPD) (
n=65, 51 males, mean age 67±9) were studied. As control group 65 healthy donors (51 males, mean age 61±14) were also evaluated. The results obtained showed that median
d-dimer levels were higher in NSCLC patients (3.0
μg/ml) compared either to COPD patients (1.1
μg/ml,
P<0.05) or controls (0.3
μg/ml,
P<0.0001). Positive TNF-α levels (>10
pg/ml) were found in 26% of NSCLC compared to 3% of COPD (
P<0.002) and 5% of controls (
P<0.0005). On the other hand, positive (>8.5
pg/ml) IL-6 levels were found in 53% of NSCLC and 21% of COPD patients, compared to 5% of control subjects (
P<0.001). Median TATc levels were elevated in either NSCLC (6.9
μg/l) or COPD (5.7
μg/l) patients compared to controls (1.8
μg/l,
P<0.0001). Elevated
d-dimer levels were significantly associated to positive TNF-α levels in patients without distant metastasis (
F=4.3,
P<0.05). Moreover, TNF-α levels (
P<0.01) were independently related to the presence of positive
d-dimer levels in patients with non-metastatic NSCLC. These results suggest that increased levels of TNF-α might be responsible for an activation of fibrinolysis in patients with NSCLC.