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Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease
Movement disorders, 2004-05, Vol.19 (5), p.571-579
Abdo, W. Farid
De Jong, Daniëlle
Hendriks, Jan C.M.
Horstink, Martin W.I.M.
Kremer, Berry P.H.
Bloem, Bastiaan R.
Verbeek, Marcel M.
2004
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Abdo, W. Farid
De Jong, Daniëlle
Hendriks, Jan C.M.
Horstink, Martin W.I.M.
Kremer, Berry P.H.
Bloem, Bastiaan R.
Verbeek, Marcel M.
Titel
Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease
Ist Teil von
Movement disorders, 2004-05, Vol.19 (5), p.571-579
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2004
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
We investigated whether cerebrospinal fluid (CSF) analysis discriminates between idiopathic Parkinson's disease (PD; n = 35) and multiple system atrophy (MSA; n = 30). The median CSF concentration of the neurotransmitter metabolites 5‐hydroxyindolacetic acid (5‐HIAA) and 3‐methoxy‐4‐hydroxyphenylethyleneglycol (MHPG) was reduced significantly (49‐70%) in MSA compared to PD. In contrast, several brain‐specific proteins (tau, neuron‐specific enolase, myelin basic protein) were elevated (130–230%) in MSA compared with those in PD. A combination of CSF tau and MHPG discriminated PD from MSA (adjusted odds ratios: tau, 27.2; MHPG, 0.14). Our data suggest that the more progressive and widespread neurodegenerative nature of MSA, as compared with PD, is reflected in the composition of CSF. We propose that CSF analysis may become part of the diagnostic work‐up of patients with parkinsonian syndromes. © 2003 Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.10714
Titel-ID: cdi_proquest_miscellaneous_71906723
Format
–
Schlagworte
Adult
,
Aged
,
Benzamides
,
Biological and medical sciences
,
Brain - diagnostic imaging
,
Brain - metabolism
,
brain-specific proteins
,
cerebrospinal fluid
,
Diagnosis, Differential
,
Electromyography
,
Enzyme-Linked Immunosorbent Assay
,
Female
,
Follow-Up Studies
,
Homovanillic Acid - cerebrospinal fluid
,
Humans
,
Hydroxyindoleacetic Acid - cerebrospinal fluid
,
Iodine Radioisotopes
,
Lactic Acid - cerebrospinal fluid
,
Male
,
Medical sciences
,
Methoxyhydroxyphenylglycol - cerebrospinal fluid
,
multiple system atrophy
,
Multiple System Atrophy - cerebrospinal fluid
,
Multiple System Atrophy - diagnosis
,
NAD - cerebrospinal fluid
,
Neurology
,
neurotransmitters
,
Parkinson Disease - cerebrospinal fluid
,
Parkinson Disease - diagnosis
,
Parkinson's disease
,
Pyrrolidines
,
Tomography, Emission-Computed, Single-Photon
,
Tomography, X-Ray Computed
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