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BibTeX
IL-10 levels in Dengue patients: Some findings from the exceptional epidemiological conditions in Cuba
Journal of medical virology, 2004-06, Vol.73 (2), p.230-234
Pérez, Ana B.
García, Gissel
Sierra, Beatriz
Alvarez, Mayling
Vázquez, Susana
Cabrera, María V.
Rodríguez, Rosmary
Rosario, Delfina
Martínez, Eric
Denny, Thomas
Guzmán, María G.
2004
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Pérez, Ana B.
García, Gissel
Sierra, Beatriz
Alvarez, Mayling
Vázquez, Susana
Cabrera, María V.
Rodríguez, Rosmary
Rosario, Delfina
Martínez, Eric
Denny, Thomas
Guzmán, María G.
Titel
IL-10 levels in Dengue patients: Some findings from the exceptional epidemiological conditions in Cuba
Ist Teil von
Journal of medical virology, 2004-06, Vol.73 (2), p.230-234
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2004
Quelle
MEDLINE
Beschreibungen/Notizen
The pathogenesis associated with Dengue haemorrhagic fever, has yet to be fully elucidated, with no definitive in vivo evidence. The exceptional epidemiological circumstances in Cuba allow the evaluation of different mediators in a well‐defined situation. In the present study, we describe the determination of levels of IL‐12, IL‐10 and RANTES in the sera of Cuban patients hospitalised with Dengue fever or Dengue haemorrhagic fever. The results showed that levels of serum IL‐10 were higher in patients than controls, and those patients with secondary infections had consistently higher levels. All the Dengue haemorrhagic fever patients had increased levels of IL‐10. In contrast, levels of IL‐12 did not differ between patients and controls. Finally, RANTES serum levels detected in patients were lower than those observed in the controls. The association of increased levels of IL‐10 in Dengue patients with a sequential infection suggests a possible role of this cytokine in the pathogenesis of Dengue disease. J. Med. Virol. 73:230–234, 2004. © 2004 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.20080
Titel-ID: cdi_proquest_miscellaneous_71896384
Format
–
Schlagworte
Adolescent
,
Adult
,
Biological and medical sciences
,
Chemokine CCL5 - blood
,
Cuba - epidemiology
,
cytokines
,
Dengue
,
Dengue - epidemiology
,
Dengue - physiopathology
,
Dengue haemorrhagic fever
,
Dengue virus
,
Epidemiology
,
Fundamental and applied biological sciences. Psychology
,
Human viral diseases
,
Humans
,
Infectious diseases
,
Interleukin-10 - blood
,
Interleukin-12 - blood
,
Medical sciences
,
Microbiology
,
Middle Aged
,
Miscellaneous
,
RANTES
,
Severe Dengue - epidemiology
,
Severe Dengue - physiopathology
,
Viral diseases
,
Virology
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